At the beginning of the Fight Night: Champion. Isaac is seen more as an arrogant, full of himself jerk who doesn't really seem like that big of a threat, but as the game progresses Isaac gets stronger and stronger, as well as much more intimidating. When Andre Bishop gets released from prison he finds out that his brother Raymond has a scheduled fight against Frost, and advises his brother to call off the fight; his plead falls on deaf ears and Raymond sets out to fight Frost. The fight, however, does not end well and Raymond loses by knockout, sustaining severe damage. Andre, in a moment of blind anger, strongly desires revenge and challenges Frost to fight him. After a grueling 10 round match, Andre wins the fight and becomes the new Heavyweight champion.
- Isaac Frost stands at approximately 6.5 feet tall and weights around 300 pounds and his boxing stats surpasses both Mike Tyson and Muhammad Ali in their prime.
- The final fight against Isaac is often referred of being one of the hardest final bosses in video game history.
- Isaac Frost's physique, strength, and overall power was based upon Ivan Drago, the villain from Rocky IV, however his face was modeled closely to that of Randy Orton.