Heggra is the sister of Steppenwolf, wife of Yuga Khan, mother of Darkseid (her younger son Uxas) and Infinity-Man (her elder son Drax), as well as the grandmother of Kalibak, Orion and Grayven. All of them, including her, are New Gods of Apokolips. She is also the mother-in-law of Suli and Tigra and Himon, the grandmother-in-law of Bekka as well as the adopted grandmother of Mister Miracle, adopted grandmother-in-law of Big Barda and adopted mother-in-law of Big Breeda.
Heggra became the supreme sovereign of Apokolips after her husband, Yuga Khan, was claimed by the Source Wall in the Promethean Galaxy.
Uxas began laying plans to claim the rulership of Apokolips. Part of this was following his elder brother to the 'Infinity Pit'. Drax was to claim his birthright, the Omega Effect, Uxas killed him and took it instead. He renamed himself Darkseid. However, he became more peaceful with the love of a good-hearted scientist named Suli. Darkseid fathers Kalibak with Suli after marrying her.
Suli's peaceful nature displeases Heggra, who then had Desaad, the chief torturer (who Darkseid had corrupted when he was younger), kill the woman. She is forced to threaten Desaad's life in order to have the task done. Heggra forced Darkseid to marry Tigra, whom she admired for her hot-tempered nature. Darkseid goes through with this despite hating Tigra; Heggra's grandson Orion is born as a result.
Eventually, Darkseid learned of Heggra's role in the death of Suli. Now more motivated to see his mother dead than ever before, he had Desaad murder the queen by poisoning her, leaving him as the unopposed ruler of Apokolips.