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|“||You understand nothing! I would do anything to save them. Anything in the entire world. The whole city can hate and revile me, I don't care! I'm not going to let anything stop me now!||„|
|~ Harumi Kiyama to Mikoto Misaka, saying she'd do anything to save the children|
Most of her appearances depict her having long wavy brown hair (which was shorter a considerable amount of time before the start of the series) and her most striking feature: bags under her eyes (which is the result of intense research in trying to revive her students). She is often seen in a white long-sleeved shirt and a brown pencil skirt and always wears a long white coat which scientists usually wear inside the laboratory. Later appearances gave her a suit to wear instead.
Harumi acts too logically and lacks common sense, which is demonstrated when she stripped in front of others without thinking about it, a result of her years being a researcher. In Toaru Kagaku no Railgun, she is revealed to be the source of one of three urban legends popularized by different Web forums within Academy City, the urban legend of the "Stripping Woman". She is shown to have low self-esteem about her body, justifying stripping in public by saying that no man would care about seeing her body.
Originally, having difficulty with children, her experiences after becoming a teacher to Child Errors. Although she is kind and considerate in people in general, she is fiercely loyal to her students, willing to make Academy City her enemy, make use of weak espers, as well as willingly cause destructive Poltergeist phenomena for their sake. In the last story arc of Railgun, she is seen to be usually downcast, putting herself to blame for what happened to her own students. She manages to take refuge to Misaka Mikoto's dedication to help others (and once noted that they share similar ideals) and Uiharu Kazari's eagerness to help her student Edasaki Banri.