The H.I.V.E. Five is a supervillain team that fought the Teen Titans occasionally in the series. They are group of teenage supervillains who commit crimes and cause trouble.

The group was led by Jinx before her defection. The team worked for Brother Blood and the H.I.V.E but later on they worked for the Brotherhood of Evil in season five.

They act as the main antagonists in "Teen Titan's Go!"