| "Griffin" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.|
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- Griffin, a mythological beast usually portrayed as a beaked lion-like animal with wings
- Griffin (The Invisible Man), the main character of H. G. Wells' novel The Invisible Man
- Griffin (DC)
- Griffin (Marvel)
- Griffin (Legendary)
- Griffin (Quest for Camelot)
- Griffin (Dragonheart: A New Beginning)
- Hawley Griffin, Alan Moore's League of Extraordinary Gentlemen incarnation of the character
- Griffin (Red Zone Cuba) the protagonist villain of the movie Red Zone Cuba.
- Gilda, a griffon that appears in My Little Pony: Friendship is Magic.
- Mrs. and Mr. Griffin, the antagonists of the film All Creatures Big and Small.