Understanding that the Secret Society of Super Villains needed a major weapon strong enough to kill members of the Justice League of America, Dr. Barbara Minerva agreed to use a plan initially thought of by team member T. O. Morrow. She had Dr. Morrow gather the scientists within the team to collect soil samples from various regions of Earth where acts of genocide took place over the past 100 years. (1908-2008) They used the soil to empower the dead body of Wonder Woman, stolen from the future, to create the sadist villain Genocide, which was brought to life through a combination of science and the magic of Felix Faust.
Dr. Minerva initially set Genocide loose at a shopping mall in downtown Washington D.C. to draw the Justice League's attention. The Department of Metahuman Affairs dispatched a team of agents, which included Agent Diana Prince to investigate the disturbance. After changing into her super powered alter ego, Genocide beat Wonder Woman to the point of near death and stole her Lasso of Truth. After having the Lasso surgically grafted into her body by the Crime Doctor, Genocide was sent to the home base of the D.M.A. to retrieve the captive Doctor Psycho. She slaughtered nearly everyone there before being attacked by the Justice League of America, and she quickly defeated John Stewart, Firestorm and Red Tornado.