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General Louse is the leader of the Army of Lice that spread throughout the school. He's the main antagonist the TV show; Arthur in the episode; "The Lousy Week".
Apparently a veteran of many previous battles, the general is a strategic leader. He sends his troops to spread nits as soon as they make contact on a new head. He does show a sense of control, as he found Buster to be uninhabitable, so he didn't even try to get him. After two long weeks, the general was the last survivor of his squad. Making a final gambit to escape to Buster and rebuild his army, his jump fell short and he was stepped on.