|“||What's the psychopath got in the bag, Jason?||„|
|~ Frank Breitkopf|
Frank never knew his father and his mother Mary Louise Breitkopf was a German imigrant prostitute living with him in Manhattan, he would always watch his mother having sex with her clients. After possibly killing Mary, he started to kill people by vivisection while travelling. He soon met a woman named Jane "Crazy Jane" Hanratty, and because she showed no fear when he was about to kill her, he spared her life. He would occasionally give her wind chimes made of his victims' bones.
Meeting Jason Gideon
After the BAU Agents were sent to investigate the deaths of his victims and the disappearance of Sheriff Georgia Davis, he was found by Agent Jason Gideon and Agent Derek Morgan while at the diner drinking his signature strawberry milkshake. After a conversation with them, Georgia was found by the authorities, traumatized inside Frank's trailer. Frank then says that he will give Gideon the location of a bus full of children he had kidnapped earlier, but only if he could leave with Crazy Jane, Gideon agrees.
Frank eventually murdered Gideon's girlfriend Sarah Jacobs and later Randall Garner's daughter Rebbeca Bryant. He also kidnaps serial killer Jeffrey Charles' would-be victim Tracy Belle. During a confration between Gideon and Breitkopf & Hanratty, realizing he would be arrested, he grabbed Jane and jumped in the front of a train, killing both Frank and Crazy Jane.
- Prentiss mentions the existence of a yet-to-be-identified "I-80 Killer" targeting co-eds in Indiana. Frank would search for victims while traveling along that particular highway. In that same episode, Reid mentions that it is very rare for two independent serial killers to be active within the same area.