Suck fist, Dr. Dork!
~ Francine to Lisa Simpson

Francine Rhenquist is a bully and the main antagonist in The Simpsons episode, Bye Bye Nerdie.

She was voiced by Kathy Griffin.


Being a new student at Springfield Elementary, other children consider Francine as a shy and withdrawn girl and they soon start gossiping her. However, Lisa who feels sympathy to the new student, attempts to befriend her, only to be socked in the eye by Francine.

This incident doesn't discourage Lisa at all and she tries to befriend Francine once again. However, it ends up with Francine biting Lisa's beloved doll's head off and locking her in her own locker. Soon after, Francine becomes Lisa's (and the other nerds') worst nightmare.

When Nelson Muntz and other bullies deny to help Lisa because they don't do girls, Lisa decides to find another way. She notices Francine bullies only nerds and leaves alone the rest of the students just like Bart. As the research continues, Lisa slowly realizes Francine can smell pheromones nerds give off and which lead her to attack them.

Although being beaten up by Francine during the research, Lisa eventually manages to isolate the chemical which is emitted by every nerd, and thus create some sort of a bully repellent. With a little help from Francine's parents who are able to lock her in the cage, Lisa can demonstrate her repellent in front of scientists. Once Lisa applies her repellent on her, Francine stops trying to attack her and just stands in front of Lisa, looking puzzled around. The scientists are excited by Lisa's experiment, until Francine smells their own pheromones and starts attacking the scientists.

          The Simpsons Villains

Springfield Republican Party
Mr. Burns | Waylon Smithers | Blue-Haired Lawyer | Birch Barlow | Lindsey Naegle

Terwilliger Family
Robert Terwilliger Jr. | Cecil Terwilliger | Francesca Terwilliger | Gino Terwilliger | Robert Terwilliger Sr. | Dame Judith Underdunk

Springfield Mafia
Fat Tony | Fit Tony

Environmental Protection Agency
Russ Cargill

Recurring Characters
Itchy| Space Mutants | Patty & Selma Bouvier | Herman Hermann | Nelson Muntz | Jebidiah Springfield | Jimbo Jones | Dolph Starbeam | Kearney Zzyzwicz | Agnes Skinner | God | Jessica Lovejoy | Artie Ziff | Baby Gerald | Wainwright Montgomery Burns | Snake Jailbird | Senator Mendoza | Matt Groening | Constance Harm

Treehouse of Horror
Kang & Kodos | Killer Krusty Doll | Zombies | Ned Flanders | The Devil | Gremlin | Count Burns | Seymour Skinner | Lard Lad | Groundskeeper Willie | Hugo Simpson II | Bart (Fly) | Witch Marge | The Collector | Killer Toupée | King Snorky | Homer's Clones | Billy the Kid | Julius Hibbert | Jonathan Frink Sr. | Muttonchop Murderer | The Blob | The Grand Pumpkin

Guest Star Characters
Black Weasel | Cesar & Ugolín | Adil Hoxha | Lucille Botzcowski | Professor Werner Von Brawn | Bob Arnold | Lyle Lanley | Kindergarten Teacher | Adolf Hitler | Robotic Richard Simmons | The Leader | Movementarians | Francine Rhenquist | Hank Scorpio | Miss Goodthighs | Molloy | Rex Banner | Dexter Colt | The Jockeys | Hell's Satans | Jack Crowley | Cooder & Spud | French Chef | Jim Hope | Larry Kidkill | Howard K. Duff VIII | White Dog | Frank Grimes, Jr. | Captain Mordecai Barrows | Clownface | Simon Cowell | Officer Krackney | Shadow Knight | Baby Button Eyes | Stanley DeGroot | Will Wright | Stubborn Ape | Mr. Dirt | Sparklemon | William Shakespeare | Julia | Andy Hamilton | Devan & Quenley Woosterfield | Comic Book Guy (Brick Like Me) | Bart Simpson's Creatures | Mav & Portia | Blue-Eyed Man | Nigel Bakerbutcher