Sister Nikoletta was a nun who was very interested in sin. Soon, it was all she desired and it made her obsession.
One day, a man looking for a place to stay gave her the Lament Configuration after sensing her desires.
It has been said that once she opened the box the Grillard cenobite came and began her transformation.
As per Barbie Wilde's story in "Hellbound Hearts", he "used" each of her holes and finally took her to Hell.
She's shaved bald, has a nail put through her nose and wires jutting out of her cheeks then splitting into six, each piece holding open a different part of her neck open. She also has some cuts on her sides.
Female made her debut in Hellraiser. After Kristy solved the puzzle box, she arrived with Pinhead and Chatterer with the intention of taking Kristy to hell with them. Female was sent back to hell when Kristy solved the box again.
Female returned in Hellraiser II. After Kristy and Julia enter hell through the puzzle box, they eventually meet with the cenobites.
Before "experiencing her flesh", they allow Kristy to wander around for a while.
As Kristy encounters them again, she shows Pinhead a picture of his human form and reminds the others that they have not always been cenobites. Female and the others are later sealed in the Pillar of Souls by Dr. Channard.