He is voiced by Joe Mantegna, who portrayed another gangster Joey Zasa in The Godfather, Part III.
Fat Tony's life seems to revolve around crime, in a similar fashion to Snake, however unlike the anarchic Snake - who commits crime at random and is often imprisoned - Fat Tony is a more subtle but no less dangerous criminal who commits his crimes (largely) in secret.
Fat Tony and his minions have had a few run-ins with Homer Simpson and his family, sometimes coming very close to killing the icon but always having their schemes foiled in some way or other.
In the season 22 episode "Donnie Fatso", Fat Tony dies of a heart attack. However, he is somewhat "revived" when his cousin Fit Tony takes over his job, gains weight, and is soon given Fat Tony's name.
- In the episode "The Homer They Fall", Fat Tony's real name is revealed to be Anthony D'Amico, while in "Insane Clown Poppy", his first name is revealed to be Marion. In his first appearance in "Bart the Murderer", however, he is identified as "William 'Fat Tony' Williams".