The EPA caught Mr. Burns illegally dumping radioactive waste in the city park and fined him three million dollars. The agency also stopped Homer from killing the Screamapillar and made him and Marge take care of it due to its being an endangered species.
Later, under the command of Russ Cargill, the EPA was primarily responsible for tricking President Arnold Schwarzenegger in encasing Springfield in a dome that later became known as Trappuccino. This action was taken in response to severe environmental degradation of the Springfield area in general, and Lake Springfield in particular. The EPA had also caught a mutant Multi-eyed squirrel in Springfield, and attributed its existence to environmental conditions in the town. After their plan to destroy Springfield failed, it was presumed the organization might have been exposed to the whole world, disbanded by the President and they've been arrested for their actions.
- EPA is similar to Cemetery Wind and the World Government, all three organizations are dictators and liars and they are prepared to eliminate innocent people to make sure no one knows their plans. Also, like Cemetery Wind, the EPA wind up getting arrested and shut down for their crimes.
- EPA is based on real-life governmental organization United States Environmental Protection Agency.