Dumazu the Destroyer is an ancient demon of death and destruction who started his religious order of ancient pre-American sorcerers known as the Cult of Dumazu, and he is the main antagonist in the videogame Ghostbusters: Sanctum of Slime. Dumazu was buried 4000 years ago but his cult survived into the present era. He sought to resurrect himself using the gathered Shards of the Relic of Nilhe.
Dumazu the Destroyer was an ancient pre-New World deity of near mythic destructive capabilities. He was worshipped in the Americas by an ancient secret society known as the Cult of Dumazu more out of fear than any true adulation. Likewise, Dumazu despised love and affection. However, Dumazu was more of a mortal demon than a all-powerful god he was believed to be and in 2010 B.C., was buried. If the Relic of Nilhe were reformed, Dumazu could be resurrected.
Dumazu was all but forgotten in the modern age. His tomb lay deep below the surface of present day New York City. In 1954, Parkview Psychiatric Hospital was built over the ancient tomb. Decades later, Dumazu spoke only to Ismael the Deceiver, a man who was the last of his cult. The Shards of the Relic of Nilhe were unwittingly gathered by the junior team of the Ghostbusters. At Parkview, Ismael took the Relic and chanted a spell. Dumazu possessed Ismael and drew the team into the another dimension. The team manages to defeat him and they return back to the physical plane.
- According to writer of Sanctum of Slime, Tom Waltz: "Again, Dumazu already existed before I came into the picture, but after I did get the gig, I checked out any references to Dumazu and found the Sumerian version. My Dumazu is loosely based upon the research I did, but I also endeavored to create some new mythology as well. So, again, a bit of familiarity with an original twist... and a little paper umbrella to make the cocktail mix presentable!".
- Dumazu is partly based on the Proto-Sumerian king, Demuzid the Shepherd, of whom later kings claimed to be the reincarnation.
- Dumazu (The Destroyer) shares the same titles with the evil entity Gozer (The Destructor) pertaining to their destructive nature and deadly powers.