Dr. Zalost is the main antagonist of the episode "The Tower of Dr. Zalost", the Season 2 finale of the Cartoon Network show Courage the Cowardly Dog.
Dr. Zalost is a depressed scientist whose goal in life was to make everyone as miserable as he was. In order for this to happen, he created bombs that, when a person is hit, they would instantly become unhappy. His proposal for his plan was laughed at, however. When he started firing his bombs at the citizens of No-Where, he was given money in order for him to stop his attack upon No-Where. Still not satisfied, he continued his attack on the citizens. This even effected Muriel Bagge. Zalost had an assistant, an anthropomorphic rat named Rat. Their relationship was rather complicated, and it's shown that Zalost was more abusive in their relationship. For example, he was angry with him for not giving him a proper hug. When Courage discovered that the antidote to the bombs was Muriel's Happy Plums, he snuck into Zalost's tower, with the help from Eustace who disguised himself as a pizza deliveryman. Zalost then entered a hangman game with Courage, while he was tied up with one of the bombs facing him. Courage won, and Zalost was enraged. He soon sent his henchman Rat after him. Courage gives him some of Muriel's plums, and he is converted into a weeping infant. He then added the Happy Plums into the bomb mix, and it created new bombs that cured everyone, including Muriel. The result of the bombs being created destroyed Zalost's Tower, however. He later arrived at the Bagge house, and saw some of the Happy Plums on the table. He ate some, and was converted into a more happier scientist, and he then immediately reconciled with his henchman Rat. He only appeared in "The Tower of Dr. Zalost".
- Zalost is a Serabic word meaning "sorrow".
- For some reason, he has green skin, purple hair, and a swollen cranium.
- Both of his arms are on the the same side of his body.
- He wears high-heel shoes and keeps dollar bills in his socks.