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Dr. Sam Isaacs

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My research will change the face of everything.
~ Dr. Sam Isaacs

Dr. Samuel "Sam" Isaacs is a secondary antagonist in the 2004 film Resident Evil: Apocalypse and the main antagonist in the 2007 film Resident Evil: Extinction. He is an Umbrella Corporation scientist, in charge of the Nemesis Program and later the Umbrella Science Division. He will return as the true main antagonist of the 2017 film Resident Evil: The Final Chapter, the final film of the series.

RE6 Main Villain

He is portrayed by Iain Glen, who also portrays Manfred Powell in the 2001 film Lara Croft: Tomb Raider.


Sam Isaacs was a tall, middle-aged Caucasian man of British background. He had sea-green eyes, and dark blonde hair. Dr. Isaacs was employed by the Umbrella Corporation sometime before the Raccoon City Outbreak. He greatly disliked his immediate superior, Major Timothy Cain, a feeling that Cain returned. Isaacs blamed Cain for the Global T-Virus Outbreak, as Cain was the man who ordered The Hive to be re-opened.

Raccoon City Outbreak

Immediately following the disaster in The Hive, it was Isaacs who, at Cain's direction, experimented on Alice and Matt Addison. But disaster struck when Cain unwisely chose to re-open the Hive, despite the containment procedures. Zombies and Lickers escaped the facility, and the T-Virus overran Raccoon City, with Alice and Addison, now subjects in the Nemesis program, still inside.

Following the bombing of Raccoon City, Isaacs was distraught to learn that both Alice and Addison were dead. But he was able to recover Alice's body from the wreckage of the helicopter she used to escape, and moved her and his work to an Umbrella facility in Detroit. After three weeks of experiments, Alice was revived with incredible new powers. Unfortunately, she retained her memories and escaped, being rescued by Jill Valentine, Carlos Olivera, and Lloyd Jefferson Wayne. But Isaacs had one last trick up his sleeve, and as Alice makes her escape, he activates "Project: Alice".

Global T-virus Outbreak

Umbrella soon had bigger problems than one escaped experiment, however. It was soon discovered that the T-virus had escaped Raccoon City, and began spreading rapidly. The world was overrun in short order, the only survivors being the civilians who stayed on the road, and Umbrella Corporation employees, who took shelter in underground facilities across the planet. Isaacs himself took charge of the research in an underground lab in the Nevada desert, trying vainly to track Alice across the wasteland that North America had become over the last five years. All the while, he maintained a combative relationship with Umbrella Chairman Albert Wesker.

Isaacs, who had begun a cloning program to recreate Alice, attempted to use the clones ' blood to "domesticate" the zombies, making them tame enough to allow humans to return to the surface. This was possible because, as he discovered, while the zombies hungered for human flesh, they derived no actual sustenance from it, and could remain active for decades or more. The results did succeed in raising the intelligence of the test subjects, but resulted in a stronger infection.

Finally realizing that only the real Alice could bring him success, Isaacs falsified orders from Wesker and took a strike team into the wastes to deactivate and retrieve her. He made camp in the ruins of Las Vegas, setting a trap with the Enhanced Zombies to kill her so they could retrieve her corpse and take a sample of her blood.

Mutation and Death

The scheme did not go as he had planned. Alice massacred the strike team with incredible speed. After an unsuccessful attempt at deactivating her, Isaacs was bitten by an Enhanced Zombie. He returned to the lab and was placed under house arrest. He injected himself with large quantities of the Anti-virus, but his condition continued to deteriorate.

Wesker, meanwhile, had enough and ordered Isaacs' immediate termination. Alexander Slater carried out the order, shooting the scientist in the heart and leaving him for dead. However, it was too late, as Isaacs had already begun to mutate, transforming into a grotesque, tentacled monster who then proceeded to slaughter everyone in the facility, beginning with Slater. Taking action, the facility's AI, the White Queen sealed him in the lower levels.

Some time later, Alice entered the facility, and after consulting with the White Queen, descended into the lower levels to kill the mutated Isaacs. They fought in a replica of the Arklay mansion, their fight eventually moving into the reconstructed "Laser Room."

Isaacs taunted Alice, telling her that she was not the future as he had previously thought, saying "I am the future." Alice responded by saying "No, you're just another asshole.", and that they were both going to die down there. As Isaacs moved in for the kill, the laser grid activated, controlled by a newly-awakened Alice clone, and sliced him into cubes, putting an end to the deranged scientist once and for all. However, it was his fake death, so this means he is alive.


Dr. Isaacs was a man of cool temperament, being knowledgeable and rational. After the Global t-virus outbreak, he worked for the good of mankind under Umbrella chairman Albert Wesker, trying to locate Alice and take a sample of her blood, thus creating a more effective cure to the T-Virus. His methods were unorthodox, however, and he regarded his work with a higher priority than the lives of his colleagues or a few civilians. In fact, one might go as far as to call Isaacs selfish, cowardly, and cruel.

This is evidenced by the fact that after the initial test of his serum designed to domesticate zombies failed, and the zombie went berserk, killing a scientist. Dr. Isaacs quickly slipped out of the room, locking the doors and sealing a second scientist inside. That scientist could have easily escaped, had Isaacs quickly let him slip out while the enraged zombie was preoccupied feasting on the first. However, Isaacs coldly watched as the man was ripped apart and eaten alive by the zombie, coolly running his fingers through his hair and adjusting his tie. His instincts for self-preservation also showed itself during the ambush in Las Vegas, when Alice attacked the Umbrella tent. Isaacs quickly fled to the nearby helicopter, leaving his colleagues to die. Isaacs maintained a wary relationship with Alexander Slater, who did not much like the scientist.


  • Superhuman Strength: Due to his unique mutation, he gained superhuman strength, significantly higher than the likes of Alice. He was bale to send her flying through the room with his hits.
  • Tentacles: His right had was capable of generating tentacles, which he can use for offensive purposes.
  • Accelerated Healing: He was able to heal large slash wounds instantaneously. This also included the immediate regeneration of his slice doff tentacles. However, he was not able to recover from being sliced into small pieces.
  • Intelligence: Despite him being a mutated creature, he still retained his human level intellect and wad fully capable of speech.



  • Isaacs is named after actor Jason Isaacs who portrayed William Birkin from the first Resident Evil film and was created to fulfill Birkin's role in the sequel.
  • Isaacs mutation is a reminiscent of the T-002 from Resident Evil.
  • He will return in final installament of the film series, Resident Evil: The Final Chapter as the main antagonist, but it is unknown how he returned from his death.

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