Dr. Mengele is one of numerous antagonistic characters found in the video-game adaptation of "I Have No Mouth and I Must Scream", like most of these characters he is a construct created by AM to torment one of the five remaining humans on Earth.

Dr. Mengele is encountered in NImdoc's scenario and is based on the real-life Nazi war criminal of the same name, it is one of the game's most controversial scenarios and resulted in the game being unfinished in Germany (as they banned Nimdoc's scenario due to the Nazism elements).