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When encountered by Sonic Doctor Plague was preparing to unleash a vial containing a virus strong enough to kill every living person in New Tek City but was stopped as Sonic used his speed to catch the vial before it could hit the ground.
Infuriated, Doctor Plague threw eight other vials containing the deadly virus - determined to be remembered as the one that destroyed New Tek City - yet Sonic caught all of these vials as well.
Ultimately Doctor Plague was captured by New Tek police and is presumably in prison for his numerous crimes.