The Diaper Mafia are a satirical criminal organization and one of the main antagonists of the Toxic Avenger series, like many of the villains in the series they are ultra-violent and murderous with no care for life and a maniacal outlook on life.

They are named after the fact they wear diapers much like adult babies and due to the nature of the film they are shown quite openly killing and maiming in over-the-top ways on-screen as well as being brutally maimed and killed in retribution by the "heroic" Toxic Avenger.