A character named Mike Peterson, who later gets the name of Deathlok, appears in the Marvel Cinematic Universe series Marvel's Agents of S.H.I.E.L.D., played by J. August Richards. He starts out as a protagonist, but later becomes a supporting antagonist in season 1. He appears in the pilot episode as a superhuman factory worker who saves a woman from an exploding building (being destroyed because of a Centipede Group experiment going wrong) with superhuman strength and jumping. Approached by eventual protagonist of the series Skye in a cafe, she warns him that S.H.I.E.L.D. might be after him soon for revealing himself as superhuman publicly. He has a conversation with Raina, a representative from the Centipede Group, where Raina doesn't seem too happy for risking the exposure of the Centipede Group's existence and plans. The next day, Mike tries convincing his boss to give him a chance to get his job back, but he refuses.
Mike gets furious and straight-up murders the factory owner, prompting Phil Coulson from S.H.I.E.L.D. to go after him. He is shot in the head with an I.C.E.R. gun by Grant Ward, then goes off to a S.H.I.E.L.D. training facility to hopefully make up for killing the factory owner. He joins up with Coulson to go after some guys using the Centipede serum that gave Mike his powers, and is seemingly blown to pieces saving his son Ace from Raina. He wakes up in a room that looks like it's from a Saw movie and has most of his body burned. A robot eye implant shows him computer text of the Clairvoyant telling him to "await further orders".
Later, he is given a robot leg by Ian Quinn, which (painfully) attaches itself to Mike's destroyed leg, making him Deathlok. He later attacks Garrett at Cybertek in the episode "Beginning of the End".