|“||I will win this! We gave up everything to destroy you animals! You don't have what it takes to win against this!! We gave up everything to put you down!||„|
Ultimate Deadpool first appears in the pages of Ultimate Spider-Man where he and his mechanically modified Reavers kidnap the X-Men, also kidnapping Spider-Man due to his visiting the X-Mansion at the time. Taking them to the island of Genosha, Deadpool and his Reavers proceed to hunt them on live TV for sport, to the joy of anti-mutant viewers everywhere. Forced to flee from attacking Reavers, the X-Men ultimately manage to unmask Deadpool, who uses his shapeshifting to trick them into thinking that he's Professor X in disguise. Though Deadpool proves to be a formidable and tenacious fighter, he is ultimately defeated by Kitty Pryde when she phases through him and sabotages his circuits. Though believed killed, Deadpool is shown at the end of the story to have in fact survived, glaring at the X-Men as they fly away while holding his damaged mask.
He later appears in the video game Spider-Man Shattered Dimensions, his personality now noticeably more in line with his Earth 616 counterpart, albeit also still malevolent. Despite this, he is shown to be more of a comedic villain, as opposed to the unsympathetic monster he was in the comics.
He was eventually stabbed to death by Earth 616 Deadpool during the events of Deadpool Kills Deadpool.
- Although lacking similarities to his mainstream counterpart, Deadpool's origins are very similar to Donald Pierce's, who was the leader of the Reavers in the mainstream universe.