All right, keep the little beasts. Do what you like with them. Drown them, for all I care! You're a fool, Anita! Why? Because I've no use for fools. You're fired! You're finished! You'll never work in fashion again! I'm through with all of you! I'll get even! Just wait! You'll be sorry, you fools! You idiots!
~ Cruella promising to get revenge on Roger and Anita over refusing to hand over the dalmatian puppies and even beating up her minions Jasper and Horace in anger.
Cruella is first seen arriving in her car to the House of De Vil. A chauffeur opens her car door for and greets her, only for her to flick a cigarette ash onto his shoe. She then exits the car and heads inside the building; first being greeted by her butler, Alonzo, and then by her employees before approaching Anita who is designing two new coats; one with stripes and another with Dalmatian spots. Anita is shocked nervously by Cruella's presence at first and tries to hide the design with the spots from her, but Cruella takes it and is entranced by it. Cruella then notices a picture of Anita's dog, Perdita and picks it up. She is charmed by her dog, but wonders why she has spots and Anita explains that Perdita is a Dalmatian. Cruella then asks a variety of question; was Perdita her inspiration, she was; does she have long hair or short, short; is her fur coarse or fine; a little coarse; much to Cruella's dismay; but finds redemption when Anita says it was very fine when she was a puppy. After this, Cruella tells Anita that the two of them need have a talk and calls her to her office and to bring the spotted coat design with her as well.
In her office, Cruella tells Anita to tell her more about the Dalmatian spots, pointing out that she did leopard spots in the 80's. Anita tells her that Dalmatian spots are a little different.
Not Ella. Ella's gone. AND CRUELLA'S BACK!!!
~ Cruella giving up on redemption and returning to her evil schemes as she reverts back to her original state.
Cruella has seemingly been released of her obsession of furs and now loves puppies and has decided to get rid of her fashion house because the clothes are made out of fur. While visiting Chloe Simon, one of the puppies nearly falls out the window and while Chloe and the other puppies try to rescue her, Cruella hears the chimes of Big Ben and she reverts back to her original obsession with spots, having a hallucination seeing black spots everywhere and she now wants 102 Dalmatian puppies for her designs. She enlists the help of another fashion designer named Jean Pierre Le Pelt and an unwilling butler named Alonso. She frames the owner of the animal shelter Kevin Sheppard for kidnapping the puppies and he is arrested. He escapes from jail and tries to help Chloe rescue the puppies, but they are trapped by Cruella. The puppies escape and Cruella tries to capture them, and at the same time Alonso redeems himself by defeating Jean-Pierre Le Pelt and freeing Chloe and Kevin while Cruella is defeated by getting baked in a cake. The police come and arrest her and Le Pelt. She is then sentenced to spend the rest of her life in prison and has her fortune 8 million pounds taken away from her and given to Kevin and the Second Chance shelter.