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The Core Brain is the main antagonist of Star Soldier R, the latest installment of the Star Soldier series. It is the leader of the Brain Forces, which attacks the Joint Forces of Earth in the year 2180. The player takes control of the Caesar prototype fighter in order to eliminate the Brain Forces, defeat the Core Brain, and save humanity.

The battle against this boss has two phases. First, you must damage the boss's arms and avoid being shot. Then you have to attack and destroy its core. When it changes color, it'll almost be destroyed. Upon defeating the boss, you complete the 5-minute mode and you fly out of the Brain Forces' base as it explodes in the background.