Christopher Reeve was a villain in the animated TV series South Park. His first appearance was in the episode "Krazy Kripples", but later appeared in episode "200".
In "Krazy Kripples", Christopher Reeve comes to town to promote stem cell research. In order to 'cure' his quadriplegia, he is shown sucking the fluids out of fetuses from a medical bio-hazard container. With each fetus he sucks dry, Reeves becomes healthier and more dependent on them for his developing super human strength.
In a reversal of character, Reeve becomes the villain when stem cell research is banned, making Gene Hackman Hack-Man, who portrayed the villain Lex Luthor, his rival. He was eventually imprisoned by the passing of a law banning stem cell research in a manner similar to the end of the movie Superman II, trapped in a 2 dimensional Phantom Zone in outer space.
He makes another appearance in "200", as one of the celebrities suing South Park (This episode aired in 2010 while Reeve In Real life died in 2004).