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Chemistro is a supervillain enemy of Luke Cage and the Avengers, whose name was taken by three different people. Curtis Carr, the first Chemistro, created a suit and gun that could fire a ray that rearranged matter into a different form. He created the gun for his company, who wanted to mainstream it, but Curtis sought to keep it for himself. He was fired, and, seeking revenge, used the alchemy gun against his former employers. In battle with the hero Luke Cage, Carr accidentally shot his own foot with the gun, turning it to steel. But it was unstable and crumbled to dust, leaving him crippled. Later he got a mechanical foot and changed his name to High-Tech, still using the alchemy gun as well as a gun tht reversed its effects. His brother Calvin then became Chemistro.

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Chemistro as he appears in The Avenger Earth' Mightiest Heroes.

In the TV show, The Avengers: Earth's Mightiest Heroes, Chemistro was one of the villains in the Vault prison when the mass breakout happened. He was knocked out by Hawkeye while getting his equipment, and later was recruited into the Masters of Evil, where he battled Hawkeye one-on-one.

Chemistro later appeared in Season 2 being pursued by the Enchantress and her Executioner after his loaction had been given to them by fellow Master of Evil the Living Laser. After reaching a dead end Chemistro confronted his persuers managing to melt the Enchantress's hand before she reformed it. In exchange for his life, He gave the Asgardians the location of Arnim Zola, but was betrayed when the Enchantress took his Alchemy Pistol and turned him into solid gold before taking his identity to infiltrate Avenger's Mansion and get close enough to Zemo to kill him.

Iron Man stated he is still alive and Wasp declared her intentions to keep him.