Catwoman is the quaternary antagonist and later tritagonist of the 2016 animated film Batman: Return of the Caped Crusaders and will return possibly as an anti-hero in the upcoming 2017 sequel Batman: The Caped Crusaders vs. Two Face. She is a criminal that tries to conquer Gotham City, but her plans were always foiled by Batman and Robin, the Dynamic Duo. She is based on the Catwoman of the 1960's Batman TV show.
After a heist in Gotham Palace and tying up the public along with Joker, Riddler and Penguin, Catwoman boarded the Jokermobile to reach a chemical factory and stole the Duplicator Ray. Batman and Robin tried to stop her and the Joker's minions, but she distracted Batman and after knocking him out, she escaped along with the other villains to a frozen food factory. Once there, she tried to make Batman a bad guy with her Bat-Grass, without apparent success. But the Dynamic Duo escaped.
After leaving the factory, Catwoman and the other villains used a U.S. rocket to reach a space station built by Russia and the United States. However, once there, the Joker, along with Riddler and Penguin, betrayed her, thinking that she would betray them because of her love for Batman. The Joker locked her into a special room and ejected her into space to kill her, but the Dynamic Duo saved her. After this, she witness Batman's fight against her three old partners in crime, leaving them unconscious. After this, Catwoman was presumably taken in custody once again.
During the time in which Batman became evil (because the effects of her Bat-Grass develop slowly), she escaped from prison and opened her own club. However, she accepted for help Robin to save Gotham City from Batman's madness. Once inside the Batcave, she injected Batman with her antidote for the effects of the Bat-Grass. However, her antidote didn't work as Batman prepared and injected himself a Bat-Anti-Antidote, and tied Catwoman along with Robin and tried to execute them in a radioactive generator, but he first kissed Catwoman as her last wish. However, after Batman left the Batcave, Catwoman was rescued by Robin.
After this, Robin and Catwoman disguised themselves as inspectors and helped the villains of the state prison, like the Mad Hatter and False Face, to escape with flying peaks and balloon shackles, except the duplicates of Joker, Riddler and Penguin. After the escape, Catwoman and Robin conducted the villain army into Gotham Palace to defeat Batman and his army of Batmans. However, they were defeated by the Batman army, but the real Batman was finally saved by the unemployed Alfred Pennyworth with a champagne antidote. After this, Commissioner Gordon and Chief O'Hara appeared to take Catwoman into custody, but she discretely escaped from the police and decided to help Batman and Robin to stop the Joker, the Riddler, and the Penguin.
After locate the criminals and their respective gang, the Dynamic Duo and Catwoman boarded the Penguin's Blimp and defeated their minions and Riddler and Penguin. After Joker's failed attempt of escape, Catwoman decided to steal the artworks stolen by the three villains, but Batman tried to convince her to abandon her bad side. Catwoman proposed her escape to Europe, for drink to coffee and kill Robin, but as Batman's refused, she returned the artworks to the Dynamic Duo and dropped herself into the chemical factory's chimney. It's currently unknown if she survived or not.
- Julie Newmar is the only actor of the 1960's Batman TV show that reprised her role as her respective villain, because Cesar Romero, Burgess Meredith, and Frank Gorshin are all deceased.
- When Batman was knocked by the Penguin, he saw three Catwoman, referencing that Catwoman was portrayed by three actress during the original 1960's Batman TV show: by Julie Newmar in the first two seasons, by Lee Meriwheter in the 1966 film, and by the late Eartha Kitt in the third and final season.
- Her proposal for Batman to go to Europe to drink coffee is a obviously reference to the final fate of Batman and Anne Hathaway's Catwoman in The Dark Knight Rises.
- It has been announced that Julie Newmar will reprise her role as Catwoman in the upcoming Return of the Caped Crusaders sequel Batman: The Caped Crusaders vs. Two Face. With the film's prologue script published in Internet, it has been revealed that Catwoman effectively survived her fall into the factory's chimney.