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He is a man of good birth and excellent education, endowed by nature with a phenomenal mathematical faculty. At the age of 21, he wrote A Treatise on the Binomial Theorem, which has had a European vogue. On the strength of it he won the mathematical chair at one of our smaller universities, and had, to all appearances, a most brilliant career before him. But the man had hereditary tendencies of the most diabolical kind. A criminal strain ran in his blood, which, instead of being modified, was increased and rendered infinitely more dangerous by his extraordinary mental powers. Dark rumors gathered round him in the University town, and eventually he was compelled to resign his chair and come down to London. He is the Napoleon of Crime, Watson, the organizer of half that is evil and nearly all that is undetected in this great city...
~ Sherlock Holmes about Professor James Moriarty in "The Final Problem"

Villains who appeared in the "Sherlock Holmes" stories by Sir Arthur Colon Doyle, and any of their adaptations.

See also

Villains at the Baker Street wiki

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