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Misanthropes

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Humanity has failed as a species. You have accomplished much with your limited capacity, but ultimately you were too greedy and too frail to ever last in the environment you have created.
~ Ultron
What can I say? We're all just bitches in the end.
~ Trixie

Villains that have a serious hatred for humanity or the nearest equivalent in their respective setting, and may even be genocidal in that regard - misanthropy can lead villains into committing terrible crimes as they no longer have compassion towards their fellow man (in fact, such villains often despise their fellow man).

Many human villains themselves (such as primate humans, cavemen or modern day humans), may also be misanthropic or "self-hating humans" as they view their species as mentally stupid, inferior, irredeemably flawed or worthless.

Many non-human villains (such as aliens, robots, animals, plants, humanoids, monsters, etc.) may also be misanthropic, as they view humans as mentally stupid, inferior, irredeemably flawed, worthless, or even oppressive.

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