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Misanthropes

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Humanity has failed as a species. You have accomplished much with your limited capacity, but ultimately you were too greedy and too frail to ever last in the environment you have created.
~ Ultron
Well, let me remind you: a Man-cub becomes Man, and Man is FORBIDDEN!!!
~ Shere Khan on his hatred towards mankind

Villains that have a serious hatred for humanity or the nearest equivalent in their respective setting, and may even be genocidal in that regard. Misanthropy can lead villains to committing terrible crimes as they no longer have compassion towards their fellow man (in fact, such villains often despise their fellow man).

Many human villains themselves (such as primate humans, cavemen, or modern-day humans) may also be misanthropic or self-hating humans, as they view their species as mentally stupid, inferior, irredeemably flawed, or worthless.

Many non-human villains (such as aliens, robots, animals, plants, humanoids, monsters, etc) may also be misanthropic, as they view humans as mentally stupid, inferior, irredeemably flawed, worthless, or even oppressive.

Good examples of misanthropes are Ultron, Godzilla, The Joker, Shere Khan, Megatron, and Cthulhu.