Villains that are enemies of the Guardians of the Galaxy.
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- Tana Nile
- Taserface (Marvel Cinematic Universe)
- Terrax the Tamer
- Thanos (2010 Marvel Animated Universe)
- Thanos (Marvel Cinematic Universe)
- Thanos (Marvel's Guardians of the Galaxy)
- Thanos (Marvel)
- Thanos (Telltale)
- Thanosi
- The Brood (Marvel)
- The Collector (Marvel Cinematic Universe)
- The Collector (Marvel)
- The Matriarch (Marvel)
- Theel
- Throk (Marvel)
- Topographical Man
- Tullk
- Tyrant (Marvel)
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