Enemies of the Marvel superhero team Fantastic Four.
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- Daredevil (Marvel Zombies)
- Darkoth
- Deathurge
- Demogorge the God-Eater
- Destroyer (Marvel)
- Devos the Devastator
- Diablo (Marvel)
- Diamondhead
- Dire Wraiths
- Doctor Doom
- Doctor Doom (1994 Film)
- Doctor Doom (2000s Films)
- Doctor Doom (Avengers: Earth's Mightiest Heroes)
- Doctor Doom (Fantastic Four: World's Greatest Heroes)
- Doctor Doom (LEGO Marvel Super Heroes)
- Doctor Doom (Marvel Animated Universe)
- Doctor Doom (Marvel Zombies)
- Doctor Doom (Marvel)
- Doctor Doom (Marvel: Ultimate Alliance)
- Doctor Doomsday
- Doctor Faustus
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- Doctor Octopus (Spider-Man: The Animated Series)
- Doctor Sun
- Doom (2015 Film)
- Doom-Bots (Lego Marvel)
- Doom-Bots (Marvel)
- Dormammu (Marvel)
- Dreadpool
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- Galactus (Avengers: Earth's Mightiest Heroes)
- Galactus (Marvel Animated Universe)
- Galactus (Marvel)
- Galactus (Marvel: Ultimate Alliance)
- Galactus (Rise of the Silver Surfer)
- Garthan Saal
- General John Ryker
- Giant Man (Marvel Zombies)
- Giganto
- Gladiatrix
- Goddess (Marvel)
- Godzilla (Marvel)
- Grandmaster (Marvel)
- Graviton (Marvel)
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- Green Goblin (Marvel Zombies)
- Green Goblin (Marvel)
- Growing Man
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- M.O.D.O.K. (Marvel)
- Machinesmith
- Mad Jim Jaspers
- Madame Viper (Marvel)
- Maelstrom's Minions
- Maggia
- Maker (Ultimate Marvel)
- Malice
- Man-Ape
- Marquis of Death
- Masters of Evil (Marvel)
- Maximus (Marvel)
- Medusa (Marvel)
- Mephisto (Marvel)
- Mesmero
- Miracle Man
- Modulus
- Mole Man (Marvel)
- Molecule Man
- Molten Man-Thing
- Morgan le Fay (Marvel)
- Mr. Fantastic (Marvel Zombies)
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- Salamandra the Fire Maiden
- Sandman (Marvel)
- Sauron (Marvel)
- Savage Hulk
- Scarlet Witch (Marvel)
- Sentry 459
- Shocker (Marvel)
- Shuma-Gorath
- Silver Surfer (Rise of the Silver Surfer)
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- Skrulls
- Skurge (Marvel)
- Snivel
- Spider-Man (Darkhold)
- Stegron
- Street (Marvel)
- Super-Apes
- Super-Skrull (Marvel)
- Supreme Intelligence
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