I'm a god. I will live forever.
~ Hades

Villains who are Deities (Gods) or have a level of power so great they are equal to such cosmic beings. Needless to say, these are some of the most powerful villains of all due to their nature.

To count as a deity, a character should also have been worshiped, either in the past or present; some deities may even require said worship to function. Sometimes, these beings rule the cosmos and do not want any body to rule in their place.