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Sonic, how I hate him. And all of that loathing has been focused into this invincible instrument of destruction! Every defeat, every humiliation at the hedgehog's hands will be returned a thousand fold by my unstoppable creation!
~ Dr. Ivo "Eggman" Robotnik while creating Infinite.
The counterpart to Mechanically Modified, Bio–Engineered villains are those who have been either created or enhanced through biological science, which includes cloning and/or manipulation of genes.