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In every universe, Peter Parker stands for heroism and responsibility, except for one. In my world, the name "Peter Parker" puts fear in the hearts of everyone who hears it. Heroism and responsibility--I destroyed every fool who held such ideals. Until this shard come to my world, I thought I was the only Peter Parker. But now, with the power of the complete Siege Perilous, I will be.
~ Wolf Spider

Villains that are either born in an alternate reality, dimension, or universe, or lives in it after permanently altering the space-time continuum. They could also have been born in the mainstream reality, but now choose to reside in another, such as Sunset Shimmer.