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You came across me so many times and yet you never saw me. Le Chiffre, Greene, Silva... (Bond: All dead.) Yeah, that's right. A nice pattern developed, you interfered in my world, I destroyed yours or did you think it was coincidence that all the women in your life ended up dead? Vesper Lynd for example, she was the big one, has he told you about her? And then of course, your beloved M, gone forever. Me! It was all me, James. It's always been me: the author of all your pain!
~ Blofeld confessing to Bond that he's responsible for Bond's recent tragedies.

The 007 novels and films are notable for their memorably despicable villains and henchmen. From Le Chiffre's encounter with Bond in the original Casino Royale novel in 1953 to Raoul Silva's scheme to exact revenge on M in the 2012 film, Skyfall, Bond's foes have been one of the most important reasons for the book and film series' continued popularity.