Caesar Caldoni was the biggest mob boss in New York history. He was best known for his rivalry with another mob boss named Webby McBain, as noted by news reporter Julio. After the Ghostbusters captured the ghosts of Webby and his gang, Caldoni is notified of their capture by his henchmen. In a later issue, he tried to attack the Ghostbusters, but he and his gang suffered the same fate as Webby and his gang. After the capture of Caesar Caldoni and his gang, the Ghostbusters dealt with an ancient supervillain named Fu Fang.