|“||I'm not letting anyone leave my town! Everyone's gonna die!||„|
|~ Brian threatening Claire|
Resident Evil 2
He is a chief of Raccoon City Police Department, but he is corrupt. It turns out that Irons is bribed by Umbrella, mostly by William Birkin, into keeping the company's secrets and allowing them to conduct experiments on living subjects, making him partly responsible for the T-Virus infecting Raccoon City. It is also heavily implied that he was a serial killer before the Raccoon City outbreak by the human skulls that are in his secret room in the police precinct.
Claire first encounters him in the police headquarters with the Mayor's daughter. Though at first he appears to be a benevolent police chief, it later turns out that he's been using the zombie outbreak to his advantage by doing whatever he wants without fear of repercussions, going as far as killing his fellow police officers as well as the mayor's daughter who he was supposed to protect, planning to keep her body as a trophy for himself. Later, she is held into gunpoint by Irons as it is revealed he worked for Umbrella and looking for his briber's daughter, Sherry. Suddenly, the embryo that Birkin injected him earlier on bursts out of his body, killing him.
In an alternate path, his fate is largely similar in that he corners Claire. However, he is instead killed by Birkin directly, being dragged down into a manhole and then having him being ripped in half from the waist down, with his top half being thrown back to the top just as Claire was about to investigate.
Resident Evil: The Darkside Chronicles
Irons appears in a cutscene where he attempts to stuff the Mayor's daughter's cadaver (it is heavily implied that he murdered her by this time). Suddenly, he is confronted by Claire and Leon, whom the latter knows who he is because he works for him. Irons sees Sherry as he is searching for her. Just then, he is killed when a monster comes out of his body.
- Originally, Brian Irons was to be an ally character, but after Resident Evil 2 was rewritten, he was changed into a villain.
- Brian Irons can be compared with Albert Wesker, as like Wesker he was secretly working for Umbrella.