| "Brain" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.|
If you came here from a link, please go back and make the right link for one of the villains listed below.
- Brain (DC) - Best known from the Teen Titans animated series
- B.R.A.I.N. - the machine from the movie 9 that is responsible for wiping out humanity
- Brain (Pinky and Brain) - a super genius lab rat who tries to conquer the world in the Warner Bros. cartoon Pinky and Brain
- Brain (Skylanders) - An Brain creature who is the last of the Ancients, and helps Kaos with his Mind Magic powers
- Brain (Kamen Rider Drive) - one of the main villains in Kamen Rider Drive
- Brainiac - Super genius that is one of Superman's antagonists in the DC comics.
- Brain Gremlin - the main antagonist of Gremlins 2: the New Batch
- Brain (Fairy Tail) - the former guild master of Oración Seis, thus the main antagonist of the latter's eponymous arc in the manga/anime series Fairy Tail