In 1891, after surviving a series of miscarriages, Amanda Mueller was accused of being the Black Womb killer. Her obstetrician was none other than Dr. Milbury, an identity used by Mr. Sinister. Mueller was married to Daniel Summers, who left Amanda with their only son because he couldn't handle the accusations.
Around World War II she was part of government research project that was gaining research on mutants. Other members included Kurt Marko (father of the Juggernaut and stepfather of Charles Xavier) and Irene Adler (lover of Mystique). Amanda must have had a slowed aging factor as she gave birth to a woman called Gloria Fontanelle who was in her early fifties in the early twentieth century.
Amanda headed the Black Womb Project in her later years. In one video she smothered a mutant child for her research.