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Big Macintosh is the main antagonist of the infamous fan-fiction known as "Sweet Apple Massacre" - a "troll pasta" in a similar manner of Cupcakes (which demonized Pinkie Pie instead).
The fanfic has Big Macintosh kidnapping, raping, torturing and killing three other ponies (in the original the Cutie Mark Crusaders) as punishment for "being too loud". The fanfic ends with Big Macintosh luring Applejack into the cellar he had previously killed the other ponies in, saying he wanted to show her a "surprise".
Although "Sweet Apple Massacre" never gained the same level of internet notoriety as Cupcakes it is considered by many to be even more violent and graphic - so much so that it has gained several variant stories, a page on KnowYourMeme plus a growing You Tube trend (which, ironically, often shows Applejack as a killer rather than Big Macintosh - which is in conflict with the original story).
It is widely speculated that unlike Cupcakes or Rainbow Factory the Sweet Apple Massacre story was designed specifically to be as gory and inappropriate as possible - which has made several label it a "forced meme" (others find the excessive violence and over-the-top cruelty to be a source of comedy, in a similar style to hyper-gorey films such as Evil Dead)