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She is portrayed by Eihi Shiina.
Yamazaki Asami is portrayed as a deeply disturbed woman who sadistically tortures and murders men who she feels have betrayed or abandoned her.
Asami was sexually abused as a child by her stepfather, and grew up to hate men. As an adult, she becomes a serial killer who victimizes men whom she associates with her abuser. She sleeps with men and then kidnaps, tortures and kills them as punishment for the abuse and abandonment she is convinced they have inflicted on her.
When a middle-aged film producer named Shigeharu Aoyama decided to find a new girlfriend, he holds a mock audition in which several girls "audition" to become his new wife. Asami attends the audition and Aoyama is instantly enthralled by her beauty and begins to date her.
After Asami tells Aoyama about her sexual abuse she suffered as a child, she asks if he loves her, and only her. He replies that he does, and they sleep together. The next morning, Asamo has disappeared without a trace, which prompts Aoyama to search for her. Meanwhile, Asami sneaks into Aoyama's house and finds a portrait of his late wife; enraged, she drugs his liquor, intent on incapacitating and punishing him. Sure enough, Aoyama has a drink when he comes home, and passes out.
When he regains consciousness, Aoyama sees a bag with something squirming and moaning inside it. A man missing both feet, his tongue, one ear and three fingers on one hand crawls out of the bag; he is one of Asami's victims. Asami appears, and the Man begs her for food. Aiyana watches, horrified, as Asami vomits into a dog dish and the man hungrily consumes it.
Aoyama collapses, and Asami injects him with a paralytic agent. She proclaims that Aoyama does not truly love her and must be punished. As he lays there, helpless, she inserts needles into his eyes and cuts off his left foot with a piano wire. Just then, Aoyama's son Sheikgo arrives home and comes to his farher's defense. Eventually Shiekgo kicks Asami down a flight of stairs, breaking her neck and killing her.
- She has been compared to Annie Wilkes from Stephen King's Misery as both seem to be caring women for both male protagonists but eventually spiral down in insanity and both have also inflicted severe injuries to the protagonists' feet. They also proclaim that they see him again after their well-deserved deaths.