He was an enforcer working for Doctor Killebrew at the Weapon X Project. Killebrew modified him by removing his nerves for pain management, and installing hypodermic implants for enhanced speed, strength and agility. Deadpool eventually killed Francis by snapping his neck.
However,when the cosmic entity of Death disappeared, he was brought back to life. He proceeded to track Deadpool down and found him in Thanos' Sanctuary as Thanos had teamed up with Deadpool to find Death.