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Achira is the demon spawn of Duaka. Her name is derived from the Mesopotamian word Achiratima, roughly translated to "Destroyer of Civilizations."
Achira's function is to spread her disease and decay on cities in order to fulfill the eleventh prophecy. Her repeated method of destruction involves taking on a willing host and releasing a plague, which causes victims to grow disgusting blotches on their faces, some form of cross-dimensional dermo-transmogrification (informally referred to by Garrett Miller as "ghost zits"). The zits on the peoples faces are her offspring that need a host to grow.
Thousands of years ago, Achira was imprisoned within an underground structure in conjunction with using incantations and talismanic objects.