The woman who would become the Abominatrix was an employee of Jasper Keaton's savings and loan company. Following government deregulation of the S&L industry, Keaton made a large profit with short-term investments. He created a genetic research division which empowered two of his employees, creating the Abominatrix and Captain Rectitude. The Abominatrix was the product of a failed medical experiment (presumably using gamma rays) to control PMS. Instead, the experiment left her permanently in that condition.
Keaton employed the Abominatrix to kidnap Louise Mason. Mason, formerly known as the Blonde Phantom back in the 1940s, had been part of the All-Winners Squad's attempt to prevent gangster Dutch Malone from stealing the nuclear warhead nicknamed Rosebud. Keaton wanted to learn the current location of Rosebud so he could use it to force the US Senate Banking Committee to give him control of the Savings and Loans. Unfortunately for Keaton, Mason did not know where it was.
The Abominatrix battled She-Hulk on several occasions while she was trying to free Mason. Mason's daughter, now the Phantom Blonde, inadvertently revealed that Rosebud was hidden in a statue in front of Rosenblatt's hotel, the Benchmark. Rosebud's detonator was connected to Rosenblatt's pacemaker, and surprisingly enough, the aged Rosenblatt died of a heart attack while in a shoot-out with Keaton's men. She-Hulk succeeded in temporarily incapacitating Abominatrix in time to hurl the missile into the empty desert, where it destroyed Keaton's resort headquarters, the Nebuchadnezzar.